~ Dr. Art Ayers contacted me yesterday for comments prior to his latest post and really, the only meaningful thing I had was to make sure Tim and Dr. BG were in for lots of credit.
I was shocked to learn that there were some paleo (meat and veggie) eaters who were getting cured with resistant starch. I didn’t know that some were sick and, as I said in a previous post, I would not have guessed that starch was good for anything, but spikes in blood sugar. I was rudely awakened by the shouts of Richard Nikoley on Free the Animal, though I suspect the sanity behind the argument came from Tim and Dr. BG (She is always right.) He presented a kind of Second Coming of Paleo with resistant starch to feed the gut flora as soluble fiber. How could I question food for flora? (How could I question Nikoley without my karate gi?) […]
Paleo Diet without Soluble Fiber is Hard on Gut Flora
People get sick on paleo, because they don’t feed their flora. Gut flora are needed to supply vitamins, short chain fatty acids and immune system stimulants. If you don’t feed your flora you get vitamin deficiencies, gut inflammation and autoimmune diseases (Treg deficiency). It is very important to remember that feeding your flora means matching the soluble fiber with the existing flora. Most people make the mistake of assuming that if they change their diet, then their flora will also change. Their flora will adapt with each of their hundred different species of gut bacteria increasing or decreasing in numbers, but no new genes will be present to digest new soluble fiber. Eating a meat diet will eventually eliminate gut bacteria needed to digest some plant materials and produce intolerances. The missing bacteria will not be regained upon return to eating plants again. [emphasis added]
Use it or lose it. Art goes on to talk a lot about the need for probiotics, and not all that stuff in yogurt, kefir, or any other lacto-strains. Rather, you need the bacteria from dirt. Ironically, it appears some of the primary keys to healing broken guts are to be found in shit pills, dirt, and even baby-poop sausages. Then you feed them well (e.g., resistant starch) to keep them established. Go read it. Perhaps—coming from a PhD in Molecular, Cellular, and Developmental Biology who has professored all over the world—some of the ignorant pip-squeaks and clowns I see in comments mostly elsewhere will get a clue, since it’s not coming from me. Yes, I’m lafing at you, and you know who you are. Keep on reading, though, even the comments I post. All y’all seem to know every last detail about me.
Tim and I owe Dr. BG AnimalPharm (link removed) (Grace) on this. Art’s post is essentially what Grace has been telling us. She blew her stack at us for some of what we said in that Latest in Paleo podcast, where we downplayed probiotics in place of feeding the gut. So, we ended up making peace by making her science editor of the book and I also went and got three soil-based probiotic products to try for myself. I’m a solid 2+ weeks into those. I’ve taken the store-bought lacto stuff, chowed yogurt, made my own kefir, but have never noticed anything particular.
That has now changed. I’ll post about it next week, along with the products I’m using. In impressed, to say the least. So yea, perhaps the reason RS doesn’t work for some, or in some cases seems to exacerbate some conditions, is that it can’t feed what doesn’t exist.
~ Successful Clinical Trial of Type 2 Drug That Works on Intestinal Organisms
BROOMFIELD, Colo.–MicroBiome TherapeuticsTM has announced positive results from its clinical trial of a microbiome modulator, NM504, in development for type 2 diabetes and pre-diabetes.
NM504 is designed to improve glucose tolerance and other metabolic parameters in patients with diabetes by shifting the gastrointestinal microbiome–the micro-organisms that inhabit the human body.
Studies have shown that people with type 2 diabetics typically have gastrointestinal dysbiosis, or microbial imbalances, that may contribute to the metabolic dysfunction associated with the condition.
The double-blind, randomized, placebo-controlled trial assessed whether NM504 administered for four weeks could improve the glucose tolerance of subjects with pre-diabetes and untreated type 2 diabetes by modulating the gastrointestinal microbiome. The study enrolled 42 subjects.
Top-line results show that twice-daily oral administration of NM504 reduced postprandial serum glucose levels and increased insulin sensitivity in these subjects. The results were statistically significant as measured by an oral glucose tolerance test. NM504 also decreased markers of chronic inflammation and blood lipids in treated subjects, and it decreased appetite as determined by a validated physician-administered scale. NM504 was well tolerated and patient compliance was excellent.
“This trial represents a milestone both for MBT and the emerging field of microbiome therapy,” noted Steve Orndorff, CEO of Microbiome Therapeutics. “NM504 is the first therapeutic shown to directly modulate the GI microbiome in diabetics, and this study is among the first randomized, placebo-controlled trials of a microbiome-based therapy to achieve a statistically significant medical outcome. We look forward to reporting more detailed data on this study at upcoming scientific meetings.”
Whether some probiotics, cheap potato starch and other fermentable fibers from food will work just as well or better is immaterial to me. Only a fraction or people will do that. Most love the attention they get from their doctors and look upon pills as a panacea. They always call it “medication.” They love to require “medication.” So, oh well. Good, I suppose.
~ NM504 is also being studied in a placebo-controlled, double-blinded, proof of concept trial testing its utility in combination with metformin in type 2 diabetes patients with adverse gastrointestinal effects.
From the same DiabetesHealth article
In a recently-published case study, NM504 demonstrated the potential to mitigate the GI side effects associated with metformin.
The gut microbiome plays an important role in regulation of metabolic processes, including digestion, absorption, and synthesis of bioactive molecules that signal physiological host mechanisms. Changes in the human gut microbiome are associated with type 2 diabetes and insulin resistance. Water-soluble dietary fibres like inulin and beta-glucan are fermented in the colon, and beta-glucan increases viscosity. Blueberries improve insulin sensitivity through an antioxidant effect. A cobiotic, consisting of purified inulin, sugar-free blueberry pomace extract, and an oat preparation of purified beta-glucan was developed for twice a day (bid) consumption as a smoothie drink to repair the gastrointestinal dysbiosis in type 2 diabetes. A 30-year-old man presented with new onset type 2 diabetes and a fasting glucose (FBS) of 375 mg/dl. Metformin 500 mg bid was initiated and increased to 1 g bid after 1 week. During the first 9 days of metformin treatment, he developed diarrhoea, but his FBS only dropped to 325 mg/dl. The cobiotic bid was added on the 9th day of metformin treatment, and after 2 days, his FBS dropped to 175 mg/dl. After 8 weeks on metformin and the cobiotic, his blood sugar was 100 mg/dl and he lost 5.5 kg. His stools became soft and formed on the cobiotic, reverted to diarrhoea when off of it for 2 days, and returned to normal on resuming the cobiotic formulation. Metformin is a safe, effective and inexpensive generic medication favouring weight loss, recommended as initial treatment of type 2 diabetes by the American Diabetes Association. However, a 20% incidence of diarrhoea limits its tolerability. A safe food supplement that can increase the efficacy of metformin and its tolerability, as occurred in this case report, would have significant positive public health consequences. A controlled clinical trial of the cobiotic with metformin is planned.
Interesting times lie ahead.
MBT is developing microbiome modulators that alter microbial populations and their environment in the gastrointestinal tract to address serious health conditions. The company’s microbiome modulators are designed to act on multiple factors, augmenting the growth of targeted desirable bacterial strains and discouraging the growth of others. NM504 is formulated to promote microbiome shifts that positively affect metabolism and weight.
We’ll see. At minimum, it appears the focus in now on actual root causes of things.