Oh the hater howls last mid-February, here and everywhere. Gotcha!
See, I dared to publish Charles Richardson's facial before and after, because having seen many of the same over the years, I knew exactly what I was seeing; no shadow of a doubt, and in an instant. Visceral. Hugely reduced inflammation, and where that always seems most remarkable is in the face.
Mr. Charles Richardson, 62. See the Original Post Here.
Basically same hate around and about. Still obvious to me. To many others as well.
So anyway, the problem here is that Charles Richardson is no dummy. While I'm not certain of his background, he emails Tim and I full-text studies that aren't open full-text access. You speculate. Moreover, he's been on a low-carb and often ketogenic diet for about 40 years, he tells me. It was beginning to ruin him, he also tells me, and "Stupid Fucking Potato Starch" changed his life.
Sly as he is, he did before and after bloodwork, so let's check it out, shall we? The only thing he changed was adding RS via Potato Starch to his otherwise LC diet.
Triglycerides (fat in the blood)
Total Cholesterol to HDL Ratio (lower is better)
TOTAL to HDL RATIO
Triglycerides to HDL Ratio (lower is better)
TRIGS to HDL RATIO
OK, so while not every single thing is optimal, most are, and he was otherwise moderate and high risk after 40 years on an LC and often Ketogenic diet. This will immediately be dismissed by 100% of LC Doctors, guaranteed. GUARANTEED! You see, most LC doctors operate on the premise that a chronic LC and/or ketogenic diet is the most optimal and healthy. Therefore, if bloodwork is "adverse," it's because there's something wrong—either the tests don't matter, there's no basis for them, or in some cases, bad is actually good (such as in high cholesterol driven by eating as much butter as you can).
I advance the bizarre notion that while there is nothing in the world wrong with natural fats in plants and animals, that the optimal way to get at them is to eat the food they come in, and to not go overboard processing them to extract the fat portion, eating them supplementally while beating your chest. Crazy, I know. And, I'll still dress my salads in EVOO.
So I've come a little full circle. Love all the natural fats. I try to minimize added fat, above the fat that's in the foods I eat.
There's one more chart, and this is a test I knew zero about. I love to learn new things, so those who know, please do elaborate in comments.
Monocytes (middle is better)
Monocytes are a type of white blood cells (leukocytes). They are the largest of all leukocytes. They are part of the innate immune system of vertebrates including all mammals (humans included), birds, reptiles, and fish. They are amoeboid in shape, having clear cytoplasm. Monocytes have bean-shaped nuclei that are unilobar, which makes them one of the types of mononuclear leukocytes (agranulocytes). Monocytes constitute 2% to 10% of all leukocytes in the human body. They play multiple roles in immune function. Such roles include: (1) replenishing resident macrophages under normal states, and (2) in response to inflammation signals, monocytes can move quickly (approx. 8–12 hours) to sites of infection in the tissues and divide/differentiate into macrophages and dendritic cells to elicit an immune response. Half of them are stored in the spleen (except in people who have undergone splenectomy). Monocytes are usually identified in stained smears by their large kidney shaped or notched nucleus. These change into macrophages after entering into the tissue spaces.
So pretty cool, eh? There's a comment somewhere I just saw where after significant time on Resistant Starch, the guy's cholesterol shifted from pattern B to pattern A. Chris Kresser:
Researchers working in this area have defined what they call Pattern A and Pattern B. Pattern A is when small, dense LDL is low, large, buoyant LDL is high, and HDL is high. Pattern B is when small, dense LDL is high, HDL is low, and triglycerides are high. Pattern B is strongly associated with increased risk of heart disease, whereas Pattern A is not.
And on the other side, someone I saw in comments had a higher particle number of cholesterol after some months.
For me, Charles' numbers suggest an hypothesis that 1) LC diets might be metabolically great for human cells, but they starve the other 90% of cells in your body, leading to adverse outcomes; and 2) that the gut biome is of such tremendous importance (recall, the only thing he changed, and he's a 4-decade-long practitioner of LC) that we're only beginning to scratch the surface.
A few closing notes:
- I keep getting these emails and other confirmation bias messages, where a chronic LCer uses potato starch, gains a couple of pounds, and says Ha! Dealt with. "Now I can speak with AUTHORITY!" You should gain weight: in biomass (lean), in colon wall width (lean), and also in your own lean tissue (lean): Resistant starch and energy balance: impact on weight loss and maintenance. So laughably, the LC Shiites are doing what the LC Shiites always do: operate from the premise that anything counter just has to be wrong a-priori, and all they have to do is figure out a way to show it.
- If you're new to all this: A Gut Microbiome, Soil-Based Probiotic, and Resistant Starch Primer For Newbies.
- The soil based probiotics are critically important. This mimics what you might have received living in the dirt as Paleoman: Probiotics: The Genetic Component of Obesity. The idea here is rather one of a unification. Perhaps obesity is genetic—but the genes in your gut microbiome outnumber those of your human cells by over 100 times. Think about that. And think of the brain-gut connection, and all the synthesized chemicals they give off that influence your desires, urges, hungers and in-turn, behaviors.
In terms of the SBOs in #3, they are pricey. What I suggest is to pound them for a couple of weeks, then back off to 1 pill, once per day, of one of the brands, rotating through. So, each bottle should last you almost 6 months, but you're getting the widest range possible.
People have asked, "well, once the microbial population is established, can't you just stop, but continue to feed via Resistant Starch?" Maybe, but we know that ancient man got a regular supply of dirt via his environment and on the food he was eating, particularly in dug-up roots. So, it'll always be a part of my regime, but I think one pill every three days or so—and periodically going with no supplementation at all—is what's currently on the table for me.
...The book is going crazy. we're aiming to get it to the publisher in time for a Holiday release. We'll see. Lots and lots to do still. Sitting at about 400 pages, over 2,000 references, with a substantial number of references having been published in 2013 and 2014.
Thanks for always staying tuned. If you like the post and/or the work, you can always say so by hitting this link when you shop Amazon, no matter what you care to buy. Costs you nothing, I get about 8.5% of your cart from Amazon. Win and win. Thanks, and always feel free to feed-back in comments.