This was to be Part 3 of The Duck Dodgers' "Hormesis Files" series, but it's way broader than that. It's beyond hormetic effects. Rather, think of it as anti-nutrients as nutrients. While you're at it, contemplate yourself...as a tender little Paleo flower, born of Trademark.
There's a long list of phytochemicals and "anti-nutrients" that people in the Paleo™ and "Bulletproof" world tend to worry about and try to avoid. Among others they include: lectins, saponins, phytate, polyphenols (tannins, isoflavones), protease inhibitors, cyanogenic glycosides, and favism glycosides. Even mycotoxin problems might be related to gut health since ruminants have little problem with them. These phytotoxins and anti-nutrients are also known as secondary metabolites. But what is never mentioned in Paleo™ circles is that there are a number of scientific papers showing benefits to consuming marginal levels of all of these toxins.
Phytic acid, lectins, phenolic compounds, amylase inhibitors and saponins have also been shown to reduce the blood glucose and insulin responses to starchy foods and/or the plasma cholesterol and triglycerides. In addition, phytic acid, phenolics, saponins, protease inhibitors, phytoestrogens and lignans have been related to reduced cancer risks. Because antinutrients can also be mitigating agents, they need re-evaluation and perhaps a change in name in the future...It is evident that both adverse and health benefits may be attributed to antinutrients in foods. It is also evident that, in many cases, the same interactions that make them antinutritive also are responsible for their beneficial effects.