More on Alzheimer’s and Ketogenic Therapy

It was last April when I pointed to a study suggesting that Alzheimer's might be linked to the whole sugar-insulin deal. That is: refined carbs and sugar, again. I pointed to this post at The IF Life in last weekend's roundup, but here it is again for reference. This adds an interesting twist, in identifying an inflammatory omega-6 fat, arachidonic acid, as a potential culprit. And all this leads to speculation and hypotheses, now, that Alzheimer's is actually a kind of third type of diabetes. Now scientists at Northwestern University have discovered why brain insulin signaling -- crucial for memory formation -- would stop working in Alzheimer's disease. They have shown that a toxic protein found in the brains of individuals with Alzheimer's removes insulin receptors from nerve cells, rendering those neurons insulin resistant. (The protein, known to attack memory-forming synapses, is called an ADDL for "amyloid ß-derived diffusible ligand.") With other research showing that levels of brain insulin and its related receptors are lower in individuals with Alzheimer's disease, the Northwestern study sheds light on the emerging idea of Alzheimer's being a "type 3" diabetes. As Mike O'Donnell says: Insulin and inflammation do run hand in hand. So could...


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Richard Nikoley

I started writing Free The Animal in late 2003 as just a little thing to try. 20 years later, turns out I've written over 5,000 posts. I blog what I wish...from diet, health, lifestyle...to philosophy, politics, social antagonism, adventure travel, expat living, location and time independent—while you sleep— income by geoarbitrage, and food pics. I intended to travel the world "homeless," but the Covidiocy Panicdemic squashed that. I became an American expat living in Thailand. I celebrate the audacity and hubris to live by your own exclusive authority and take your own chances. ... I leave the toilet seat up. Read More

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