My Podcast Interview with Dave Asprey & Armi Legee at The Bulletproof Executive

A month os so back I had a chance to get with Dave & Armi and chat for about an hour about many things self-experimental in the whole Paleo realm.

It was a really good time, magnified later by the opportunity to meet Dave at a local steakhouse for dinner. And let me tell you what fun that was. Bio-Hacking Geek doesn’t begin to describe Dave.

At any rate, here’s the link to the podcast page and I hope you take the time to have a listen. Here’s what’s covered.

  1. How did you get interested in ancestral dieting and health?
  2. Richard, if you aren’t wearing a loin cloth and clubbing small animals to death, aren’t you a total hypocrite? Isn’t a diet based on what our ancestors ate kind of stupid?
  3. How has eating paleo allows you to perform better at work and as a human being?
  4. Do you think eating paleo improves mental performance as well as physical performance?
  5. You recently completed a month long “pure paleo” experiment where you ate almost all paleo foods. Did you see any improvements?
  6. Speaking of puritanism, what do you think of supplementation? Do you take any supplements, and if so, why?
  7. Is it okay to still seek information about health from non-paleo bloggers? Or should we write them off if we don’t agree with everything they say?
  8. You once referred to the paleo diet as a “diet of no diet.” Could you explain what that means?
  9. What are the biggest changes you’ve mad to your diet/lifestyle since starting paleo? How have your ideas evolved over time?
  10. What are your thoughts on n=1 testing in general?
  11. Who are your favorite paleo bloggers, and what are your absolute go-to sources of information about health and fitness?
  12. What are some of the best ways to convince others to at least try paleo?
  13. Are there any tools you use on a daily basis for cooking paleo foods?
  14. What are the most underrated parts of health? (sleep, mindfulness, stress, etc)
  15. Could you tell the audience what will be included in your new Free The Animal Book?
  16. Where can people learn more about you?


  1. Razwell on February 9, 2012 at 11:18

    Excellent. It was nice to hear the history. 2006 – 2007 was a great time breaking away from the mainstream “expert organizations ” such as AHA etc. and discovering things for ourselves.

  2. Razwell on February 9, 2012 at 12:23

    I also wanted to say thanks for that information about vitamin K2, Richard, in the podcast . That is PROFOUND information about the rats’ arteries. I did not know that. :)

    Mice and rats are A LOT like us, especially in regard to obesity, ( they are super valid obesity research subjects) and probably coronary artery disease also.

    I hope this takes us somewhere. Science truly is a group effort. Other profound information which will alter the way we view coronary artery disease forever is the discovery that it is a disease not of the vessel lumen, but rather the vessel wall – profound information.

    Take care,


    • Richard Nikoley on February 9, 2012 at 12:26


      The effects of vitamin K (phylloquinone: K1 and menaquinone-4: MK-4) on vascular calcification and their utilization in the arterial vessel wall were compared in the warfarin-treated rat model for arterial calcification. Warfarin-treated rats were fed diets containing K1, MK-4, or both. Both K1 and MK-4 are cofactors for the endoplasmic reticulum enzyme gamma-glutamyl carboxylase but have a structurally different aliphatic side chain. Despite their similar in vitro cofactor activity we show that MK-4 and not K1 inhibits warfarin-induced arterial calcification. The total hepatic K1 accumulation was threefold higher than that of MK-4, whereas aortic MK-4 was three times that of K1. The utilization of K1 and MK-4 in various tissues was estimated by calculating the ratios between accumulated quinone and epoxide species. K1 and MK-4 were both equally utilized in the liver, but the aorta showed a more efficient utilization of MK-4. Therefore, the observed differences between K1 and MK-4 with respect to inhibition of arterial calcification may be explained by both differences in their tissue bioavailability and cofactor utilization in the reductase/carboxylase reaction. An alternative explanation may come from an as yet hypothetical function of the geranylgeranyl side chain of MK-4, which is a structural analogue of geranylgeranyl pyrophosphate and could interfere with a critical step in the mevalonate pathway.”

  3. Armi Legge on February 9, 2012 at 14:43

    Hey Richard,

    Thanks so much for talking with us, it was great fun. You are a wealth of knowledge.

    @Razwell, I’m glad you enjoyed the podcast. Please let us know if there are any guests you would like to see on the show. Also, you do have to be careful with rat studies. Unfortunately, they aren’t a great test subject for obesity research. They convert glucose to fat 10 times faster than humans, they exhaust glycogen levels far faster, and they regulate appetite in different ways.



  4. Armi Legge on February 10, 2012 at 08:56

    Thanks Razwell, we actually did have Sean Croxton on the show. That guy is awesome. Here’s a link:

    We’ll have to agree to disagree about the mice. Small details – no worries. :) I’m interested and open minded to new ideas, do you have any research refuting what I said about glucose metabolism?

    Thanks man,


  5. Razwell on February 9, 2012 at 18:05

    Thank you Richard :)

    Thanks as well, Armi . Perhaps you could have on Sean Croxton?

    P.S. With all due respect , that information is completely incorrect about mice.

    Mice make absolutely FABULOUS research subjects for obesity. They are our CLOSEST relative among research model organisms. In fact, mice are SO genetically close to humans that some researchers refer to them as “pocket sized humans”. Some of the greatest advances in obesity research was done on MICE. Scientists confirmed they had the proper frmaework. Dr. Douglas Coleman was a GENIUS in obesity research- one of the greatest.

    There are all types of fabulous cutting edge genetics research going on using mice. Geneticists use them for VERY good reason.

    Several outspoken Internet gurus ( from Australia) are dead wrong about their mice assertions. It seems to be common misinformation on the Internet . Genuine scientists already know they are fabulous for obesity research. I know my stuff. I have researchered morbid obesity almost obsessively for 3 years.

    Debunking the INternet mice myth is one of my pet peeves.

  6. Razwell on February 10, 2012 at 12:30

    Hi Armi

    It’s OK. :)

    I have no personal stock in this either way, I just like to dispell common pervasive Internet myths.

    Mice have given us tremendous gifts.

    Geneticists use mice for very , very good reason. They are the closest to humans out of ANY “model organism. ” Their genome is remarkably similar – 99 % like our own

    They have proven themselves extremely helpful and very SUPER valid useful model organisms for major advances in obesity, coronary artery disease, cystic fibrosis and even addiction- and much more- the list goes on and on. Off the top of my head that’s what I listed.

    Of course hey are not 100 % perfect, or EXACTLY like u. There are *some* differences.

    But they are super valid – the very best research model organisms avilable to science for human disease study. No question about that. They are AWESOME for the study of the neurobiology of human obesity. There are unique experiemnts that can be performed on mice which tell us a lot about the neurobiology of obesity- whcih is where the real research is headed.

    The hole Internet insulin hypothesis / Gary Taubes bashing vs the “eat less, move more” crowd and their ramblings is equaivalent to askin “What cheese is the moon made of?” They are both removed from where real obesity research is headed. Neurobiology and the beneficial gut hormone cocktail that is created from the physical re- routing of bariatric surgery is where the genuine , cuttign edge scientists are looking at.

    The Internet spends too much time asking “what cheese the moon is made of?” The Taubes bashers do not realize they are just as incomplete. Both camps are missing the picture completey.

    Getting back to mice:

    Here is one reputable academic site among many , many others demonstrating this:

    Take care,

  7. Razwell on February 10, 2012 at 05:27

    You did an excellent job on the podcast, Armi. You and Richard make for good listening. Nothing personal about the mice thing. I just like to get the message out there.

    All the best,


  8. Razwell on February 10, 2012 at 12:40

    *All genuine , reputable geneticists fully recognize that the mouse is absolutely CRITICAL to research into human diseases.

    Here are some more links: ( there are more but this is what I have now)

    My keys are worn out and the “w” in the word Whole did not register LOL !

    Best Wishes,


  9. Bodhi on February 11, 2012 at 05:59

    I enjoyed the interview and rest to the podcast. I hadn’t heard of the Bulletproof Executives site until now. Their information looks really interesting.

  10. Weekly Roundup #10 | Ideal Man | The 21 Convention on February 13, 2012 at 10:30

    […] Richard Nikoley is interviewed on Bullet Proof Executive (link). […]

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